The present study attempted to explore teachers and instructors' job satisfaction and itsrnrelation with self-esteem, taking some selected demographic variables. The study wasrndone (through two Likert-tlJpe scales i. e. Job satisfaction survey and self-esteem scales) onrna total of 284 (208 males and 76 females) teachers and instructors in Dessie town, whornwere selected via proportional stratified random sampling. Data were analyzed usingrnmean, standard deviation, pearson-product moment correlation, multiple regression andrnOne-way ANOV A. Results showed that such demographic variables as age, number ofrndependants and work experience were positively and significantly related to jobrnsatisfaction, while marital status was related negatively and significantly with jobrnsatisfaction. But sex and educational level of the participants did not show a significa ntrncorrelation. All the independent variables (sex, age, marital status, number ofrndependents, educational level, work experience and self-esteem) taken togetherrnsignificantly predicted job satisfaction. Age was found to be the best predictor among thernvariables entered in the equation. It was also noted that, there was no statisticallyrnsignificance difference on job satisfa ction among teachers and instructors. On the basis ofrnthese results, discussion and conclusion were made. Finally, some recommendations arernforwarded for possible intervention and future research.