The threat of psychosocial problems, such as stigma andrndiscrimination may prevent people living with HIV/ AIDS fromrnrevealing their status to others, and serve as the major barrier to HIVrntreatment and ART adherence. The purpose of this study was tornassess whether psychosocial problems existed or not in clients ofrnART, and then if it was real, which gender was more susceptible tornthe existing problem. In this study, data were analyzed from 165rnrespondents of male and female respondents who have beenrnselected purposively from 552 total populations, ART users, atrnDebrebrehan Zonal Hospital. Of which 91(55.2%) of respondentsrnwere f emales and 74(44.8%) of them were males. The results of chisquarernanalysis for both psychological and social variables arernsignificant. This is not true for gender analysis. Data were collectedrnby the use of questionnaires, FGD and in-depth interview. Accordingrnto the findings of this study, psychological and social problems, suchrnas depression, stress, and fe eling of shame, stigma andrndiscrimination are those that influence access and adherence of ARTrnsignificantly. With regards to the services offered and ART relatedrnpsychosocial problems of the two genders, it is insignificant. Inrnconclusion, there are psychosocial problems related to ART drugrnaccess and adherence on h, the users as well as the public. Hence,rnproviding effective counseling service for ART users, creatingrnawareness for the public to minimize stigma and discrimination,rnsocial discussion about HIV/ AIDS and its treatment, provision ofrnadequate education, empathic understanding and social support willrnbe suggested