The major objective of this study wa to probe the problems of Micro and Small ManufacturingrnEnterpri es in De sie town in relation to their marketing activities (more specifically of theirrnproduct, price, promotion, and location cases). In order to gain relevant data from thernrespondents, both quantitative and qualitative methods were used in this study. To obtainrnprimary data, self-administered questionnaires were distributed to respondents of Micro andrnmall Manufacturing Enterprise operators/managers upon whom stratified sampling technique 'rnwas used in sample selection. On top of this, semi-structured interview was also used to obtainrnprimary data from the heads of Micro and Small Enterprise Expanding Office and MunicipalityrnOffice of Dessie town respectively. The SPSS version 15 was used to process the primary data.rnThe findings of this study showed that products of respondents of Micro and SmallrnManufacturing Enterprises were not differentiated from competitors' offers. Similarly, the greatrnmajority of the respondents pointed out that they had no sufficient market for their products atrncurrent production level. Many respondents had the following opinion related to price: they didrnnot take salaries/wages of family members working in their enterprise while pricing products;rnthey did not get cheaper suppliers of inputs; and they preferred cost of production to whatrncustomers able to pay in their emphasis. For all respondents, word of mouth communication wasrnthe basic tool played significant role for the sale of products. However, other tools of promotionrnsuch as trade fairs, in store promotion, advertising board, radio broad casting, localrnnewspapers, catalogue, magazine, and packages were not used by the majority of respondents .rnNext, they did not even set plan and allocate budget at the beginning of a year to promote theirrnproduct. Lastly, selling/manufacturing locations were not convenient in terms of infrastructures,rnpeople traffic, people's living standard, and security cases. To overcome these, the Micro andrnSmall Enterprise Expanding Office and other concerned parties should provide periodicalrntraining and other supports to enterprise managers of Micro and Small manufacturingrnbusinesses. Micro and small manufacturing enterprise operators should also strengthen theirrnefforts in the areas where they showed betterments and strive to minimize their weaknernresulted from themselves .