The purpose of the present study was to investigate the factors of job stressrnand job satisfaction among TVET teachers in Tigray and discuss its relevancernto TVET. The research was conducted with the assumption that if such factorsrnare identified, efforts can be made to eliminate or reduce the effects of thosernvariables which lead to stress or and enhance those which lead torns atisfaction. A sample of 180 teachers was randomly drawn from 308rnteachers. Participants completed a questionnaire on demographic variablesrnand 20 subscales of teachers' stress and job satisfaction measures.rnQuantitative statistics such as mean, standard deviation, Product MomentrnCorrelation, ANOVA and linear regression techniques were employed betweenrnmeasures. The result of the study has shown that female respondent teachersrnhad a lower level of satisfaction and highly stressed as compared to thernmales. Diploma graduate teachers showed relatively lower job satisfactionrnand higher stress compared to BA/ BSC graduates. Teachers of Industrialrnarea were with high stress (as compared to the business teachers) inrnleadership style and less satisfied in achievement need. However, age andrnexpenence on job stress and satisfaction did not show a significantrncontribution in the study. The results of regression showed that workingrnenvironment, salary and benefits and responsibility were very importantrnfactors to job satisfaction. The regression analysis also indicated extrinsicrnvariables to be the most explaining variables as compared to intrinsicrnvariables on the overall effect of job satisfaction. Moreover, most teachers feltrnstressed on factors such as role over/oad, working condition, peer support, andrnleadership styles. The relationship between overall job Stress and jobrnsatisfaction was found to be negative and significant. Finally the resultsrnappear to have managerial and research implications. It is envisaged that thernidentification of the specific sources of stress will shade light in to thernproblems of TVET teachers that make their job particularly difficult.