Seeds of Glinus lotoides, Linne (Molluginocea) and flowers of Hagenia abyssinica Gmel,rn(Rosaceae) are used traditionally in the treatement of tapeworm infestion in Ethiopia. Previousrnstudies on anthelmintic activities of both plants have confirmed their traditional claims. However,rntheir detailed toxicities were not yet conducted. In these studies, single and repeated dose oralrntoxicity studies in rats were conducted using methanolic extracts of seeds of Glinus lotoides andrnaqueous extracts flowers of Hagenia abyssinica.rnDoses of 0, 1000 and 5000 mg/kg of crude extract of Glinus lotoides were employed in singlerndose toxicity study while doses of 0. 250, 500, and 1000 mg/kg were used in repeated doserntoxicity studies. In the single dose toxicity test, oral administration of 5000 mg/kg of Glinusrnlotoides produced mortality in two females and one male on day 4. No significant differences inrnbody and organ weight between controls and treated animals were observed in survived animalsrnat both dose levels. Therefore LD50 of the extract might be greater than or equal to 5000 mg/kg.rnMoreover, both gross and microscopic examinations of organs did not show detectablerndifferences between controls and treated animals of both sexes. In repeated dose toxicity studies,rnno mortality was observed when these varying doses of the extracts were administered per day forrna period of 28 days. There were no significant differences in the body weight, absolute andrnrelative organ weights between controls and treated animals of both sexes. Hematologicalrnanalysis showed no differences in most parameters examined. In the clinical chemistry analysis,rnno significant change occurred. Pathologically, neither gross abnormalities norrnhistopathological changes were observed. Therefore, the NOEL could be greater than or equal torn1000 mg/kg in rats and none of the organs are considered target during both single and repeatedrnstudies.rnThe aqueous flower extracts of Hagenia abyssinica was tested for its single and repeated doserntoxic effect on rats of both sex. Studies at 5000 mg/kg (limit test) and at three dose levels (500,rn1000, and 2000 mg/kg) for the main study were conducted orally on 5 rats per sex per dose withrnconcurrent control receiving distilled water in single dose study. No toxic sings were noted at allrndose levels and there were no significant differences in mean body weights of the treated grouprncompared to control. Therefore, LD50 of the extract is greater than 5000 mg/kg. In repeated dosernstudies, three doses of the extract (350, 750, and 1500 mg/kg) were administered orally to 5 ratsrnper dose per sex for 28 days and various toxicologic indices tested. Cage side observation, bodyrnweight, biochemical and morphologic pathology observation did not show significant differencesrnacross the group. Therefore, none of the organs have shown to be the target; Hagenia abyssinicarnis safe in rats at all doses studied and the NOEL could be greater than or equal to 1500 mg/kg inrnrats.rnKeywords: Glinus lotoides, Hagenia abyssinica, Mettere, Kosso, LD50, NOEL, single doserntoxicity, repeated dose toxicity