In Ethiopia, a number of zoonotic diseases are known to have public health and economicrnimportance both in humans and animals. The present study has particularly given emphasisrnto brucellosis because of its morbidity and significance to the public health and the economyrnof the country. A cross-sectional study has been conducted in Horro Guduru AnimalrnProduction and Research Center and its srrounding, Western Ethiopia to estimate thernseroprevelence of bovine brucellosis and its associated risk factors from December 2017 tornMarch 2018. A total of 812 cattle from three stations (districts) were randomly selected forrnserology finding and questionery surveys from 102 respondents were collected usingrnquestionery format. All sample sera collected were screened by Rose Bengal Plate Test andrnpositive samples were finally confirmed by compitetive-Enzyme Linked Immuno SorbetrnAssay and Complement Fixation Test. Out of 812 samples tested, an overall seroprevalencernof 0.73 (95% CI: 0.241-3.461) was recorded. The higher seroprevalence, 4.41% (95% CI:rn0.028-3.473) was observed around Fincha district as compared to Horro Guduru Animalrnproduction center (0.31%) and Guduru district (0.99%). A Chi-square computed statisticalrnanalysis indicated that origin (χ2=7.951: P