Cross-sectional study was conducted in South Omo and Gamo Goffa zones of Southern Nations Nationalities and People Regional State from September 2004 to February 2005 to determine seroprevalence and associated risk factors, isolate the causative agent, evaluate test agreement, and validate community perception. A multistage sampling was used in pastoral and mixed production systems. A total of 1033 goatsâ€™ and 80 sheepâ€™s sera were collected for serological study. Additionally nasal swabs, lung tissue and thoracic fluid were collected from sick goats and all samples were submitted to National Veterinary Institute for isolation. Participatory disease search in pastoral area and questionnaire survey in mixed farming area were conducted. Proportional piling and matrix scoring were used to characterize major diseases of goats including their causes and signs. Based on the CFT results seroprevalence was vary among selected woreda. In Hammer and Benna tsemay woreda it was almost equal 15.5%, whereas in Boreda (32%) and Arbaminch (23%) was observed. The overall mean seroprevalence in study area was16.5%. There was no significant difference observed in seroprevalence among age groups, even though seroprevalence increases as the age increases. Pastoral and mixed farming area showed 15.5 and 18.4% seroprevalence, respectively. However, seroprevalence obtained using cELISA showed significant difference between production systems, age category and flock size category by univariate analysis (p0.05) with seroprevalence except flock size and age category greater than 4years (P