This study was conducted from December 2004 to March 2005 in two selected woredas in northwestern Ethiopia, with the objective of assessing the impact of a strategic treatment intervention on ruminant fasciolosis. The study was conducted using questionnaire survey, cross sectional prevalence study and experimental study involving naturally infected animals with Fasciola spp. and treatment with triclabendazole at a dose rate of 10mg/kg bodyweight orally. A total of 384 cattle from Fogera woreda and 368 sheep from Mecha wereda were involved in cross section prevalence study. 167 animals (80 cattle and 87 sheep) were selected from the study population and grouped into three (group I, one- time treated group, group II two-times treated group and group III, positive control) to serve as experimental animals. Out of the 752 faecal samples collected from cattle and sheep for cross sectional study, 283 (37.6%) were found positive for fasciolosis with a specific prevalence of 37.2% in cattle and 38% in sheep. Analysis of the findings among different age groups indicated the existence of a significant difference in prevalence of fasciolosis both in cattle and sheep (P