This study was conducted from September 2011 to May 2012 in selected districts of Arsi Zone of Oromia Regional State with the objectives of determining the epidemiology of M.haemolytica, P.multocida and B.trehalosi through studying their isolation rates among different contributing host and environmental risk factors. Moreover, the efficacy of Tetracycline, Penicillin, Amoxicillin and Gentamicin against representative isolates was determined. A total of 384 local sheep were examined and 109 isolates were identified. 65 isolates (59.6%) of the total isolates were M.haemolytica, 33 isolates (30.3%) P.multocida and 11 isolates (10.1%) were B.trehalosi. The distribution of general positives among different age groups of sheep were found varying significantly (P