Cross sectional purposive type of study on entereopathognes associated in calf diarrhea inrndairy farms of, Muke turi, Debre tisege and Fitche towns, North Shewa Zone, wasrnconducted from November 2013 to April 2014 with the objective of identification ofrnenteropathogens associated with calf diarrhea, investigating of potential risk factorsrnrelated to the occurrence of enteropathognes causing calf diarrhea, determination of E.rncoli biotype and antimicrobial susceptibility patterns of bacterial isolates. Non-probabilityrnpurposive sampling was used for the selection of farms and calf samples and 105rndiarrheic calf samples were used in this study. Standard isolation techniques were used tornidentify the enteropathognes from diarrheic cases. The overall occurrence of E. coli,rnsalmonella, cryptosporidium, eimeria and giardia found in this study were 69.5%, 25.7%,rn27.6, 38.1% and 22.9% respectively. Single and mixed infection was common in thisrnstudy. Among the potential risk factors age and age at first colotrum feeding were thernfactors that were found significantly associated with risk of occurrence of E. coli causingrndiarrhea (P= 0.01) using Chi square test and younger calves were more susceptible thanrnolder caves by odds of 14.74 times. Other risk factors (sex, breed) were not significantlyrnassociated with the occurrence of enteropathogns. Thirteen different biotypes of E. colirnwere found on the fermentation of nine sugars biotype XIII and XII were the dominantrnbiotype found in calf diarrhea. Ciprofloxacin, trimethoprim-sulfamethoxazole andrngentamycin were found to be susceptible for the bacterial isolates whereas erythromycinrnand tetracycline were developed resistance and most of the bacterial isolates showedrnmultidrug resistance pattern. The occurrence rate of E. coli, salmonella, cryptosporidiumrnand giardia causing diarrhea were serious problem in dairy caves. Great care should berngiven to the age of calves and time of first colostrum ingestion. Further epidemiologicalrnand microbiological studies on enteropathogns causing calf diarrhea to identify thernserotype, virulent gene of the bacteria strongly recommended, in addition, the higher raternof antimicrobial resistance indicates the strategic use of the drugs in the future.