Livestock plays vital roles in generating income to farmers, creating job opportunities, ensuring food security, providing services, contributing to an asset, social, cultural and environmental values and sustain livelihoods. Thus, provision of quality veterinary clinical service is crucial for the country to benefit the most from its livestock resource. The study was conducted from September 2019 to March 2020 in Veterinary Teaching Hospital of Addis Ababa University, and around Bishoftu town with objectives of performing various surgical cases to develop surgical skill in different surgical procedures in domestic animals and determining post-operative complications that could occur after surgical procedures. During the study period, a total of sixteen cases were studied and based on, history, general physical examinations and observations were thoroughly assessed to determine the type of case and surgical intervention. When the animal was found to require specific surgical intervention; patients were prepared for aseptic procedures and preoperative animal preparation, anesthetic protocols depending on type of animal species. Different domestic animal species that need surgical intervention were included in this study. The various surgical cases were: cesarean sections, spaying, castrations, atresia ani, herniorhaphy and horn amputation were performed during the study period. After surgical operation: postoperative care, surgical complications and outcomes were recorded. Of all the operated animals, 93.75% (15/16) were recovered and cured where as 6.25% (1/16) was died. Generally, swelling, bleeding, anorexia, surgical site inflammation and loss of body condition were observed in some of the patients and recorded as a post-operative complication. Use of appropriate aseptic and surgical techniques and post-operative care can be suggestive in order to minimize post-operative complications.