This study assessed the impacts of urbanization on surface water quality and identify the sourcesrnof pollution on Keha River in Gondar town. Urbanization and anthropogenic activities are thernkey factor causing water quality degradation as we go downstream along Keha River.rnBased on Keha watershed land use land cover in1999,2004,2006 and 2017, it is shownrnthat there is significant land use change of the bare land, grassland and agricultural landrnconverted into urban land use and Keha River water quality has deteriorate in the past 15rnyears. The critical source of pollutions are industries like Moha soft drink industry,rnGondar hospital, Kedame Gebeya Commercial market, a lot of hotels and restaurantsrnamong others. To analyze the river water quality fourteen (14) different strategic samplingrnsites were selected. The analysis consisted of in situ and laboratory analysis of samplesrnusing standard methods. The result indicated that the range of PH (5.9-8.97mg/l),rnConductivity (142-1231 us/cm), Turbidity (8-1072 NTU), Dissolved Oxygen (7.4-2.1mg/l),rnBOD (4.1-217mg/l), TDS (102-1298mg/l), Alkalinity (89-508mg/l), Total Hardness(103283mg/l),rnIron(0.15-0.76),rnChromium(0.02-0.42),rnManganese(0.02-3.9),rnPhosphate(1.3732.7mg/l),rnrnNitrate(35.4-178mg/l), Total coliform counts(2.9-495) and E.Coli counts (2273.8) forrnrainyrnandrndryrnseasons.rnAtrnallrnsamplingrnsitesrnexceptrnupstream ofrnKeharnRiverrnthernrnPhysico-rnchemicalrnandrnbacteriologicalrnresultsrnofrnwaterrnsamplesrnwerernabovernthernEthiopianrnrnandrnrnWHO standard limit indicated that Keha River was polluted. Except upstream ofrnKeha River, at all sites the Dissolved Oxygen (DO) is less than 5 mg/l that is below thernWHO and Ethiopian minimum standard limit. High nitrate and phosphate cause ofrneutrophication, high total coliform and high E.coli lead to water borne disease and therndeath of the communities especially children because some people like the daily laborersrnand street children were used for drinking this polluted River within the study area. It isrntherefore concluded that the river in the study area is polluted and not fit for domestic use.rnIt is recommended that the water of Keha River should not be used directly for domesticrnpurposes. It is also recommended that an IWRM approach be used in order to solve thernpollution problem. Keha River health restorative work is require for multiple importancernsuch as ecosystem regeneration, water quality improvements, reduce any negative impactsrnon the water resources and aquatic life of Keha River.